Expression of LGALS8 in cancer - Summary - The Human Protein Atlas

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LGALS8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LGALS8
Gene description	Lectin, galactoside-binding, soluble, 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA030491
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030491

GENE INFORMATION
Gene name	LGALS8 (HGNC Symbol)
Synonyms	PCTA-1
Description	Lectin, galactoside-binding, soluble, 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q43
Chromosome location (bp)	236518000 - 236552981
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116977 (version 83.38)
Entrez gene	3964
UniProt	O00214 (UniProt - Evidence at protein level)
neXtProt	NX_O00214
Antibodypedia	LGALS8 antibodies

PROTEIN BROWSER

LGALS8-001	LGALS8-002	LGALS8-003	LGALS8-006	LGALS8-007	LGALS8-008	LGALS8-011	LGALS8-012	LGALS8-013	LGALS8-014	LGALS8-023	LGALS8-024	LGALS8-026	LGALS8-027	LGALS8-201	LGALS8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGALS8-001 ENSP00000435460 ENST00000526589	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002317 [plasma cell differentiation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0031295 [T cell costimulation] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	359 aa 40.4 kDa	No	0
LGALS8-002 ENSP00000355543 ENST00000366584	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	317 aa 35.8 kDa	No	0
LGALS8-003 ENSP00000342139 ENST00000341872	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	317 aa 35.8 kDa	No	0
LGALS8-006 ENSP00000385999 ENST00000406509	Q5T3P9 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	208 aa 23.2 kDa	No	0
LGALS8-007 ENSP00000437040 ENST00000526634	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	317 aa 35.8 kDa	No	0
LGALS8-008 ENSP00000431398 ENST00000527974	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	359 aa 40.4 kDa	No	0
LGALS8-011 ENSP00000238181 ENST00000238181	H7BXD8 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	175 aa 19.6 kDa	No	0
LGALS8-012 ENSP00000435632 ENST00000481485	E9PJ77 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	106 aa 12.1 kDa	No	0
LGALS8-013 ENSP00000405504 ENST00000454943	B1ANM0 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	168 aa 18.9 kDa	No	0
LGALS8-014 ENSP00000309576 ENST00000352231	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	359 aa 40.4 kDa	No	0
LGALS8-023 ENSP00000398630 ENST00000430527	E9PRN3 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	121 aa 13.9 kDa	No	0
LGALS8-024 ENSP00000434860 ENST00000323938	E9PN19 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	290 aa 32.6 kDa	No	0
LGALS8-026 ENSP00000431884 ENST00000525042	F6V2D4 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	300 aa 34 kDa	No	0
LGALS8-027 ENSP00000437007 ENST00000529489	E9PPL1 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	43 aa 4.7 kDa	No	0
LGALS8-201 ENSP00000410843 ENST00000416919	F6V2D4 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	300 aa 34 kDa	No	0
LGALS8-202 ENSP00000408657 ENST00000450372	O00214 [Direct mapping] Galectin-8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] GO:0098792 [xenophagy] Show all	359 aa 40.4 kDa	No	0

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The Human Protein Atlas

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