Cell atlas - CD48 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD48
Gene description	CD48 molecule
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (U-266/70, U-266/84, HMC-1, Daudi)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Nucleoli fibrillar center (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA055146
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, U-266/84, HMC-1, Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoli (fibrillar center).

Main location

Plasma membrane (supported)

Additional location

Nucleoli fibrillar center (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055146	REH	Plasma membrane
HPA055146	REH	Cytosol
HPA055146	U-2 OS	Nucleoli fibrillar center
		Plasma membrane
		Cytosol

GENE INFORMATION
Gene name	CD48 (HGNC Symbol)
Synonyms	BCM1, BLAST, hCD48, mCD48, SLAMF2
Description	CD48 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	160678746 - 160711851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117091 (version 83.38)
Entrez gene	962
UniProt	P09326 (UniProt - Evidence at protein level)
neXtProt	NX_P09326
Antibodypedia	CD48 antibodies

PROTEIN BROWSER

CD48-001	CD48-002	CD48-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD48-001 ENSP00000357025 ENST00000368046	P09326 [Direct mapping] CD48 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	243 aa 27.7 kDa	Yes	1
CD48-002 ENSP00000357024 ENST00000368045	P09326 [Direct mapping] CD48 antigen Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	169 aa 19.4 kDa	Yes	0
CD48-003 ENSP00000484431 ENST00000613788	A0A087X1S7 [Direct mapping] CD48 antigen Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003823 [antigen binding] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042110 [T cell activation] GO:0043234 [protein complex] GO:0045576 [mast cell activation] GO:0046658 [anchored component of plasma membrane] Show all	252 aa 28.9 kDa	Yes	0