Expression of CD48 in cancer - Summary - The Human Protein Atlas

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CD48

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD48
Gene description	CD48 molecule
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HMC-1, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enhanced (lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. CAB002497
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), breast cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002497

GENE INFORMATION
Gene name	CD48 (HGNC Symbol)
Synonyms	BCM1, BLAST, hCD48, mCD48, SLAMF2
Description	CD48 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	160678746 - 160711851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117091 (version 83.38)
Entrez gene	962
UniProt	P09326 (UniProt - Evidence at protein level)
neXtProt	NX_P09326
Antibodypedia	CD48 antibodies

PROTEIN BROWSER

CD48-001	CD48-002	CD48-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD48-001 ENSP00000357025 ENST00000368046	P09326 [Direct mapping] CD48 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	243 aa 27.7 kDa	Yes	1
CD48-002 ENSP00000357024 ENST00000368045	P09326 [Direct mapping] CD48 antigen Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	169 aa 19.4 kDa	Yes	0
CD48-003 ENSP00000484431 ENST00000613788	A0A087X1S7 [Direct mapping] CD48 antigen Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003823 [antigen binding] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042110 [T cell activation] GO:0043234 [protein complex] GO:0045576 [mast cell activation] GO:0046658 [anchored component of plasma membrane] Show all	252 aa 28.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.