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CDC20

GENERAL INFORMATION

Gene name

 CDC20

Gene description

 Cell division cycle 20

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Group enriched (appendix, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in proliferating cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Nuclear staining was viewed as off target and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA055288 , CAB004525
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, testis)

GENE INFORMATION

Gene name

 CDC20 (HGNC Symbol)

Synonyms

 CDC20A, p55CDC

Description

 Cell division cycle 20 (HGNC Symbol)

Entrez gene summary

 CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 43358955 - 43363203

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117399 (version 83.38)

Entrez gene

 991

UniProt

 Q12834 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12834

Antibodypedia

 CDC20 antibodies

PROTEIN BROWSER
CDC20-001
CDC20-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC20-001
ENSP00000308450
ENST00000310955
Q12834 [Direct mapping]
Cell division cycle protein 20 homolog
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031915 [positive regulation of synaptic plasticity]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0090129 [positive regulation of synapse maturation]
Show all
 499 aa
54.7 kDa 		No 0
CDC20-002
ENSP00000361540
ENST00000372462
Q12834 [Direct mapping]
Cell division cycle protein 20 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031915 [positive regulation of synaptic plasticity]
GO:0040020 [regulation of meiotic nuclear division]
GO:0042826 [histone deacetylase binding]
GO:0043234 [protein complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050773 [regulation of dendrite development]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0090129 [positive regulation of synapse maturation]
Show all
 499 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.