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SYF2

GENERAL INFORMATION

Gene name

 SYF2

Gene description

 SYF2 pre-mRNA-splicing factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues. JV

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA018265
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018265

GENE INFORMATION

Gene name

 SYF2 (HGNC Symbol)

Synonyms

 CBPIN, DKFZp564O2082, fSAP29, NTC31, p29

Description

 SYF2 pre-mRNA-splicing factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 25222679 - 25232502

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117614 (version 83.38)

Entrez gene

 25949

UniProt

 O95926 (UniProt - Evidence at protein level)

neXtProt

 NX_O95926

Antibodypedia

 SYF2 antibodies

PROTEIN BROWSER
SYF2-001
SYF2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYF2-001
ENSP00000236273
ENST00000236273
O95926 [Direct mapping]
Pre-mRNA-splicing factor SYF2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007369 [gastrulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0044822 [poly(A) RNA binding]
GO:0048568 [embryonic organ development]
GO:0071010 [prespliceosome]
GO:0071012 [catalytic step 1 spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071014 [post-mRNA release spliceosomal complex]
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 243 aa
28.7 kDa 		No 0
SYF2-004
ENSP00000346330
ENST00000354361
O95926 [Direct mapping]
Pre-mRNA-splicing factor SYF2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0044822 [poly(A) RNA binding]
GO:0071010 [prespliceosome]
GO:0071012 [catalytic step 1 spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071014 [post-mRNA release spliceosomal complex]
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 201 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.