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ARID1A

GENERAL INFORMATION

Gene name

 ARID1A

Gene description

 AT rich interactive domain 1A (SWI-like)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005456 , CAB016334
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005456
CAB016334

GENE INFORMATION

Gene name

 ARID1A (HGNC Symbol)

Synonyms

 B120, BAF250, BAF250a, C10rf4, C1orf4, P270, SMARCF1

Description

 AT rich interactive domain 1A (SWI-like) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26696033 - 26782104

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117713 (version 83.38)

Entrez gene

 8289

UniProt

 O14497 (UniProt - Evidence at protein level)

neXtProt

 NX_O14497

Antibodypedia

 ARID1A antibodies

PROTEIN BROWSER
ARID1A-001
ARID1A-002
ARID1A-003
ARID1A-007
ARID1A-009
ARID1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARID1A-001
ENSP00000320485
ENST00000324856
O14497 [Direct mapping]
AT-rich interactive domain-containing protein 1A
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001843 [neural tube closure]
GO:0003205 [cardiac chamber development]
GO:0003408 [optic cup formation involved in camera-type eye development]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006344 [maintenance of chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0030900 [forebrain development]
GO:0031491 [nucleosome binding]
GO:0042766 [nucleosome mobilization]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0055007 [cardiac muscle cell differentiation]
GO:0060674 [placenta blood vessel development]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
GO:1901998 [toxin transport]
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 2285 aa
242 kDa 		No 0
ARID1A-002
ENSP00000387636
ENST00000457599
O14497 [Direct mapping]
AT-rich interactive domain-containing protein 1A
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042766 [nucleosome mobilization]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
Show all
 2068 aa
218.3 kDa 		No 0
ARID1A-003
ENSP00000363267
ENST00000374152
O14497 [Direct mapping]
AT-rich interactive domain-containing protein 1A
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042766 [nucleosome mobilization]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
Show all
 1902 aa
205.9 kDa 		No 0
ARID1A-007
ENSP00000432473
ENST00000524572
E9PQW6 [Direct mapping]
AT-rich interactive domain-containing protein 1A
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006338 [chromatin remodeling]
GO:0090544 [BAF-type complex]
Show all
 123 aa
13.6 kDa 		No 0
ARID1A-009
ENSP00000390317
ENST00000430799
H0Y488 [Direct mapping]
AT-rich interactive domain-containing protein 1A
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006338 [chromatin remodeling]
GO:0090544 [BAF-type complex]
Show all
 1182 aa
129.4 kDa 		No 0
ARID1A-201
ENSP00000478955
ENST00000615191
A0A087WUV6 [Direct mapping]
AT-rich interactive domain-containing protein 1A
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006338 [chromatin remodeling]
GO:0090544 [BAF-type complex]
Show all
 1141 aa
121.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.