A majority of cancer cells showed moderate positivity. Strong positivity was seen in a few cases of melanomas, skin, cervical and testicular cancers. Several breast cancers were negative.
STK11 (HGNC Symbol)
Serine/threonine kinase 11 (HGNC Symbol)
Entrez gene summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]