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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STK11
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STK11

Gene description

Serine/threonine kinase 11

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA017254 , CAB016231 , CAB022105
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017254
CAB016231
CAB022105

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic staining was observed in most cancer tissues. Several gliomas, lymphomas, endometrial and renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues were weakly stained or negative. Moderate cytoplasmic positivity was observed in cases of colorectal cancers and gliomas.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer cells showed moderate positivity. Strong positivity was seen in a few cases of melanomas, skin, cervical and testicular cancers. Several breast cancers were negative.

GENE INFORMATION

Gene name

STK11 (HGNC Symbol)

Synonyms

LKB1, PJS

Description

Serine/threonine kinase 11 (HGNC Symbol)

Entrez gene summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

1177558 - 1228435

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118046 (version 83.38)

Entrez gene

6794

UniProt

Q15831 (UniProt - Evidence at protein level)

neXtProt

NX_Q15831

Antibodypedia

STK11 antibodies

PROTEIN BROWSER

STK11-001
STK11-004
STK11-007
STK11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK11-001
ENSP00000324856
ENST00000326873
Q15831 [Direct mapping]
Serine/threonine-protein kinase STK11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001558 [regulation of cell growth]
GO:0001894 [tissue homeostasis]
GO:0001944 [vasculature development]
GO:0002039 [p53 binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006914 [autophagy]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007286 [spermatid development]
GO:0007409 [axonogenesis]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010212 [response to ionizing radiation]
GO:0016020 [membrane]
GO:0030010 [establishment of cell polarity]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030275 [LRR domain binding]
GO:0030295 [protein kinase activator activity]
GO:0030308 [negative regulation of cell growth]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032147 [activation of protein kinase activity]
GO:0036398 [TCR signalosome]
GO:0036399 [TCR signalosome assembly]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0043276 [anoikis]
GO:0044281 [small molecule metabolic process]
GO:0045059 [positive thymic T cell selection]
GO:0046777 [protein autophosphorylation]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050772 [positive regulation of axonogenesis]
GO:0050852 [T cell receptor signaling pathway]
GO:0051645 [Golgi localization]
GO:0051896 [regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
GO:0070062 [extracellular exosome]
GO:0071493 [cellular response to UV-B]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097484 [dendrite extension]
GO:1900182 [positive regulation of protein localization to nucleus]
Show all
433 aa
48.6 kDa
No 0
STK11-004
ENSP00000467912
ENST00000585851
K7EQN8 [Direct mapping]
Serine/threonine-protein kinase STK11
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
153 aa
17.1 kDa
No 0
STK11-007
ENSP00000477641
ENST00000585748
A0A087WT72 [Direct mapping]
Serine/threonine-protein kinase STK11
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
21 aa
2.5 kDa
No 0
STK11-201
ENSP00000467240
ENST00000586243
K7EP59 [Direct mapping]
Serine/threonine-protein kinase STK11
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
432 aa
48.5 kDa
No 0

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The Human Protein Atlas project is funded
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