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KPTN

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GENERAL INFORMATION

Gene name

 KPTN

Gene description

 Kaptin (actin binding protein)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Nucleoplasm (approved), Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA041710 , HPA041796
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & nucleoplasm.

Main location

 Cytosol (approved)

Additional location

 Nucleoplasm (approved), Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041710 A-431 Cytosol
HPA041710 U-2 OS Cytosol
HPA041710 U-251 MG Cytosol
HPA041796 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA041796 U-2 OS Nucleoplasm
Cytosol
HPA041796 U-251 MG Nucleoplasm
Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 KPTN (HGNC Symbol)

Synonyms

 2E4

Description

 Kaptin (actin binding protein) (HGNC Symbol)

Entrez gene summary

 This gene encodes a filamentous-actin-associated protein, which is involved in actin dynamics and plays an important role in neuromorphogenesis. Mutations in this gene result in recessive mental retardation-41. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47475144 - 47484268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118162 (version 83.38)

Entrez gene

 11133

UniProt

 Q9Y664 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y664

Antibodypedia

 KPTN antibodies

PROTEIN BROWSER
KPTN-001
KPTN-005
KPTN-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPTN-001
ENSP00000337850
ENST00000338134
Q9Y664 [Direct mapping]
Kaptin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005815 [microtubule organizing center]
GO:0006928 [movement of cell or subcellular component]
GO:0007015 [actin filament organization]
GO:0007605 [sensory perception of sound]
GO:0015629 [actin cytoskeleton]
GO:0030426 [growth cone]
GO:0032420 [stereocilium]
GO:0048471 [perinuclear region of cytoplasm]
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 436 aa
48.1 kDa 		No 0
KPTN-005
ENSP00000472291
ENST00000600271
M0R238 [Direct mapping]
Kaptin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 43 aa
4.8 kDa 		No 0
KPTN-007
ENSP00000469446
ENST00000595554
M0QXX4 [Direct mapping]
Kaptin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
Show all
 263 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.