Expression of KPTN in cancer - Summary - The Human Protein Atlas

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KPTN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KPTN
Gene description	Kaptin (actin binding protein)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA041710 , HPA041796
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041710	HPA041796

GENE INFORMATION
Gene name	KPTN (HGNC Symbol)
Synonyms	2E4
Description	Kaptin (actin binding protein) (HGNC Symbol)
Entrez gene summary	This gene encodes a filamentous-actin-associated protein, which is involved in actin dynamics and plays an important role in neuromorphogenesis. Mutations in this gene result in recessive mental retardation-41. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	47475144 - 47484268
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118162 (version 83.38)
Entrez gene	11133
UniProt	Q9Y664 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y664
Antibodypedia	KPTN antibodies

PROTEIN BROWSER

KPTN-001	KPTN-005	KPTN-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KPTN-001 ENSP00000337850 ENST00000338134	Q9Y664 [Direct mapping] Kaptin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005634 [nucleus] GO:0005815 [microtubule organizing center] GO:0006928 [movement of cell or subcellular component] GO:0007015 [actin filament organization] GO:0007605 [sensory perception of sound] GO:0015629 [actin cytoskeleton] GO:0030426 [growth cone] GO:0032420 [stereocilium] GO:0048471 [perinuclear region of cytoplasm] Show all	436 aa 48.1 kDa	No	0
KPTN-005 ENSP00000472291 ENST00000600271	M0R238 [Direct mapping] Kaptin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.8 kDa	No	0
KPTN-007 ENSP00000469446 ENST00000595554	M0QXX4 [Direct mapping] Kaptin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0007015 [actin filament organization] GO:0015629 [actin cytoskeleton] Show all	263 aa 29.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.