Cell atlas - TTR - The Human Protein Atlas

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TTR

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	TTR
Gene description	Transthyretin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Group enriched (Hep G2, CACO-2, U-2 OS, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002550
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, CACO-2, U-2 OS, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002550	CACO-2	Golgi apparatus
	HPA002550	U-251 MG	No staining

GENE INFORMATION
Gene name	TTR (HGNC Symbol)
Synonyms	CTS, CTS1, HsT2651, PALB
Description	Transthyretin (HGNC Symbol)
Entrez gene summary	This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	31591726 - 31599021
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118271 (version 83.38)
Entrez gene	7276
UniProt	P02766 (UniProt - Evidence at protein level)
neXtProt	NX_P02766
Antibodypedia	TTR antibodies

PROTEIN BROWSER

TTR-001	TTR-201	TTR-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTR-001 ENSP00000237014 ENST00000237014	P02766 [Direct mapping] Transthyretin E9KL36 [Target identity:100%; Query identity:100%] Transthyretin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0007603 [phototransduction, visible light] GO:0030198 [extracellular matrix organization] GO:0042562 [hormone binding] GO:0042572 [retinol metabolic process] GO:0042802 [identical protein binding] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	147 aa 15.9 kDa	Yes	0
TTR-201 ENSP00000477599 ENST00000610404	A0A087WT59 [Direct mapping] Transthyretin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042572 [retinol metabolic process] GO:0070324 [thyroid hormone binding] GO:0070327 [thyroid hormone transport] Show all	185 aa 20.1 kDa	Yes	0
TTR-202 ENSP00000479174 ENST00000613781	A0A087WV45 [Direct mapping] Transthyretin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042572 [retinol metabolic process] GO:0070324 [thyroid hormone binding] GO:0070327 [thyroid hormone transport] Show all	139 aa 15.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.