Cell atlas - ALDH8A1 - The Human Protein Atlas

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ALDH8A1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	ALDH8A1
Gene description	Aldehyde dehydrogenase 8 family, member A1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055414
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome.

Main location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055414	HEK 293	Centrosome
	HPA055414	Hep G2	Centrosome

GENE INFORMATION
Gene name	ALDH8A1 (HGNC Symbol)
Synonyms	ALDH12
Description	Aldehyde dehydrogenase 8 family, member A1 (HGNC Symbol)
Entrez gene summary	This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
Chromosome	6
Cytoband	q23.3
Chromosome location (bp)	134917390 - 134950122
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118514 (version 83.38)
Entrez gene	64577
UniProt	Q9H2A2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2A2
Antibodypedia	ALDH8A1 antibodies

PROTEIN BROWSER

ALDH8A1-001	ALDH8A1-002	ALDH8A1-003	ALDH8A1-006	ALDH8A1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH8A1-001 ENSP00000265605 ENST00000265605	Q9H2A2 [Direct mapping] Aldehyde dehydrogenase family 8 member A1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0042573 [retinoic acid metabolic process] GO:0042574 [retinal metabolic process] GO:0042904 [9-cis-retinoic acid biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	487 aa 53.4 kDa	No	0
ALDH8A1-002 ENSP00000356819 ENST00000367845	Q9H2A2 [Direct mapping] Aldehyde dehydrogenase family 8 member A1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0042573 [retinoic acid metabolic process] GO:0042574 [retinal metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	433 aa 47.3 kDa	No	0
ALDH8A1-003 ENSP00000437161 ENST00000460753	H0YF40 [Direct mapping] Aldehyde dehydrogenase family 8 member A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	134 aa 15.1 kDa	No	0
ALDH8A1-006 ENSP00000356821 ENST00000367847	Q9H2A2 [Direct mapping] Aldehyde dehydrogenase family 8 member A1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0042573 [retinoic acid metabolic process] GO:0042574 [retinal metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	437 aa 48 kDa	No	0
ALDH8A1-007 ENSP00000435297 ENST00000534012	E9PKV1 [Direct mapping] Aldehyde dehydrogenase family 8 member A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0055114 [oxidation-reduction process] Show all	15 aa 1.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.