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ALDH8A1

GENERAL INFORMATION

Gene name

 ALDH8A1

Gene description

 Aldehyde dehydrogenase 8 family, member A1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in hepatocytes and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026292 , HPA055414
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026292
HPA055414

GENE INFORMATION

Gene name

 ALDH8A1 (HGNC Symbol)

Synonyms

 ALDH12

Description

 Aldehyde dehydrogenase 8 family, member A1 (HGNC Symbol)

Entrez gene summary

 This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 134917390 - 134950122

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118514 (version 83.38)

Entrez gene

 64577

UniProt

 Q9H2A2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2A2

Antibodypedia

 ALDH8A1 antibodies

PROTEIN BROWSER
ALDH8A1-001
ALDH8A1-002
ALDH8A1-003
ALDH8A1-006
ALDH8A1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH8A1-001
ENSP00000265605
ENST00000265605
Q9H2A2 [Direct mapping]
Aldehyde dehydrogenase family 8 member A1
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 487 aa
53.4 kDa 		No 0
ALDH8A1-002
ENSP00000356819
ENST00000367845
Q9H2A2 [Direct mapping]
Aldehyde dehydrogenase family 8 member A1
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 433 aa
47.3 kDa 		No 0
ALDH8A1-003
ENSP00000437161
ENST00000460753
H0YF40 [Direct mapping]
Aldehyde dehydrogenase family 8 member A1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 134 aa
15.1 kDa 		No 0
ALDH8A1-006
ENSP00000356821
ENST00000367847
Q9H2A2 [Direct mapping]
Aldehyde dehydrogenase family 8 member A1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 437 aa
48 kDa 		No 0
ALDH8A1-007
ENSP00000435297
ENST00000534012
E9PKV1 [Direct mapping]
Aldehyde dehydrogenase family 8 member A1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0055114 [oxidation-reduction process]
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 15 aa
1.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.