Fields »
ABOUT
HELP
BLOG
ARG1

GENERAL INFORMATION

Gene name

 ARG1

Gene description

 Arginase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression liver and subsets of bone marrow cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA003595 , HPA024006 , CAB009434 , CAB056159
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 ARG1

Synonyms

Description

 Arginase 1 (HGNC Symbol)

Entrez gene summary

 Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 131573144 - 131584332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118520 (version 83.38)

Entrez gene

 383

UniProt

 P05089 (UniProt - Evidence at protein level)

neXtProt

 NX_P05089

Antibodypedia

 ARG1 antibodies

PROTEIN BROWSER
ARG1-001
ARG1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARG1-001
ENSP00000357066
ENST00000368087
P05089 [Direct mapping]
Arginase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0004053 [arginase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006525 [arginine metabolic process]
GO:0006527 [arginine catabolic process]
GO:0006595 [polyamine metabolic process]
GO:0016813 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 322 aa
34.7 kDa 		No 0
ARG1-004
ENSP00000349446
ENST00000356962
P05089 [Direct mapping]
Arginase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004053 [arginase activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006525 [arginine metabolic process]
GO:0006527 [arginine catabolic process]
GO:0006595 [polyamine metabolic process]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0009611 [response to wounding]
GO:0009635 [response to herbicide]
GO:0010042 [response to manganese ion]
GO:0010043 [response to zinc ion]
GO:0010269 [response to selenium ion]
GO:0010963 [regulation of L-arginine import]
GO:0014075 [response to amine]
GO:0016813 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines]
GO:0019547 [arginine catabolic process to ornithine]
GO:0030145 [manganese ion binding]
GO:0030324 [lung development]
GO:0032496 [response to lipopolysaccharide]
GO:0032964 [collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0033197 [response to vitamin E]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043200 [response to amino acid]
GO:0043434 [response to peptide hormone]
GO:0044281 [small molecule metabolic process]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0048545 [response to steroid hormone]
GO:0048678 [response to axon injury]
GO:0051597 [response to methylmercury]
GO:0060056 [mammary gland involution]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070062 [extracellular exosome]
GO:0070207 [protein homotrimerization]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071353 [cellular response to interleukin-4]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 330 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.