Cell atlas - RPN2 - The Human Protein Atlas

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RPN2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	RPN2
Gene description	Ribophorin II
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA025922
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA025922	A-431	Endoplasmic reticulum
	HPA025922	U-2 OS	No staining
	HPA025922	U-251 MG	Nuclear bodies
	HPA025922	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	RPN2 (HGNC Symbol)
Synonyms	RIBIIR, RPN-II, RPNII, SWP1
Description	Ribophorin II (HGNC Symbol)
Entrez gene summary	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	37178410 - 37241623
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118705 (version 83.38)
Entrez gene	6185
UniProt	P04844 (UniProt - Evidence at protein level)
neXtProt	NX_P04844
Antibodypedia	RPN2 antibodies

PROTEIN BROWSER

RPN2-001	RPN2-002	RPN2-003	RPN2-004	RPN2-006	RPN2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPN2-001 ENSP00000237530 ENST00000237530	P04844 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000421 [autophagosome membrane] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0006412 [translation] GO:0006464 [cellular protein modification process] GO:0006487 [protein N-linked glycosylation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0007568 [aging] GO:0008250 [oligosaccharyltransferase complex] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042493 [response to drug] GO:0043022 [ribosome binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	631 aa 69.3 kDa	Yes	3
RPN2-002 ENSP00000362735 ENST00000373632	Q5JYR7 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Ribophorin II, isoform CRA_d Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	345 aa 37.2 kDa	Yes	0
RPN2-003 ENSP00000362724 ENST00000373622	P04844 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006464 [cellular protein modification process] GO:0006487 [protein N-linked glycosylation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008250 [oligosaccharyltransferase complex] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	615 aa 67.7 kDa	Yes	2
RPN2-004 ENSP00000399137 ENST00000456102	Q5JYR4 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	167 aa 18.3 kDa	No	0
RPN2-006 ENSP00000409580 ENST00000437329	Q5JYR3 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	138 aa 15.5 kDa	No	2
RPN2-007 ENSP00000399404 ENST00000456400	H0Y5M1 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016021 [integral component of membrane] Show all	147 aa 16.8 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.