Few cases of testicular cancer along with rare cervical cancers exhibited strong membranous positivity. Rare cases of lung and liver cancers showed moderate positivity. Remaining cancers were weakly stained or negative.
ABCG2 (HGNC Symbol)
ABCP, BCRP, CD338, EST157481, MXR
ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]