We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ABCG2
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCG2

Gene description

ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)

Protein class

Cancer-related genes
CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, BEWO, RPMI-8226)
HPA (normal tissue):Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct luminal membrane expression in the intestine and seminal vesicle as well as distinct expression in endothelial cells of CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA054719
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY

HPA054719

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of testicular cancer along with rare cervical cancers exhibited strong membranous positivity. Rare cases of lung and liver cancers showed moderate positivity. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

ABCG2 (HGNC Symbol)

Synonyms

ABCP, BCRP, CD338, EST157481, MXR

Description

ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

4

Cytoband

q22.1

Chromosome location (bp)

88090264 - 88231322

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118777 (version 83.38)

Entrez gene

9429

UniProt

Q9UNQ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UNQ0

Antibodypedia

ABCG2 antibodies

PROTEIN BROWSER

ABCG2-001
ABCG2-002
ABCG2-003
ABCG2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG2-001
ENSP00000237612
ENST00000237612
Q9UNQ0 [Direct mapping]
ATP-binding cassette sub-family G member 2
A0A024RDD4 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family G (WHITE), member 2, isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0031966 [mitochondrial membrane]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042803 [protein homodimerization activity]
GO:0042908 [xenobiotic transport]
GO:0044281 [small molecule metabolic process]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
Show all
655 aa
72.3 kDa
No 6
ABCG2-002
ENSP00000426917
ENST00000515655
Q9UNQ0 [Direct mapping]
ATP-binding cassette sub-family G member 2
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0031966 [mitochondrial membrane]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042803 [protein homodimerization activity]
GO:0042908 [xenobiotic transport]
GO:0044281 [small molecule metabolic process]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
Show all
611 aa
67.5 kDa
No 6
ABCG2-003
ENSP00000426916
ENST00000505480
H0YAF1 [Direct mapping]
ATP-binding cassette sub-family G member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
150 aa
15.9 kDa
No 0
ABCG2-004
ENSP00000426934
ENST00000503830
H0YAF3 [Direct mapping]
ATP-binding cassette sub-family G member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
130 aa
13.6 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.