Expression of ABCG2 in cancer - Summary

GENERAL INFORMATION
Gene name	ABCG2
Gene description	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Protein class	Cancer-related genes CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, BEWO, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct luminal membrane expression in the intestine and seminal vesicle as well as distinct expression in endothelial cells of CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA054719
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA054719

GENE INFORMATION
Gene name	ABCG2 (HGNC Symbol)
Synonyms	ABCP, BCRP, CD338, EST157481, MXR
Description	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	88090264 - 88231322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118777 (version 83.38)
Entrez gene	9429
UniProt	Q9UNQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNQ0
Antibodypedia	ABCG2 antibodies

PROTEIN BROWSER

ABCG2-001	ABCG2-002	ABCG2-003	ABCG2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCG2-001 ENSP00000237612 ENST00000237612	Q9UNQ0 [Direct mapping] ATP-binding cassette sub-family G member 2 A0A024RDD4 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family G (WHITE), member 2, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0006879 [cellular iron ion homeostasis] GO:0008559 [xenobiotic-transporting ATPase activity] GO:0015232 [heme transporter activity] GO:0015886 [heme transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0031966 [mitochondrial membrane] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0042908 [xenobiotic transport] GO:0044281 [small molecule metabolic process] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] Show all	655 aa 72.3 kDa	No	6
ABCG2-002 ENSP00000426917 ENST00000515655	Q9UNQ0 [Direct mapping] ATP-binding cassette sub-family G member 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0006879 [cellular iron ion homeostasis] GO:0008559 [xenobiotic-transporting ATPase activity] GO:0015232 [heme transporter activity] GO:0015886 [heme transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0031966 [mitochondrial membrane] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0042908 [xenobiotic transport] GO:0044281 [small molecule metabolic process] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] Show all	611 aa 67.5 kDa	No	6
ABCG2-003 ENSP00000426916 ENST00000505480	H0YAF1 [Direct mapping] ATP-binding cassette sub-family G member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 15.9 kDa	No	0
ABCG2-004 ENSP00000426934 ENST00000503830	H0YAF3 [Direct mapping] ATP-binding cassette sub-family G member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 13.6 kDa	No	0