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ABCG2

GENERAL INFORMATION

Gene name

 ABCG2

Gene description

 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)

Protein class

 Cancer-related genes
CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine)
GTEx:Mixed
FANTOM5:Tissue enhanced (seminal vesicle, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct luminal membrane expression in the intestine and seminal vesicle as well as distinct expression in endothelial cells of CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA054719
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, small intestine)

GENE INFORMATION

Gene name

 ABCG2 (HGNC Symbol)

Synonyms

 ABCP, BCRP, CD338, EST157481, MXR

Description

 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 88090264 - 88231322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118777 (version 83.38)

Entrez gene

 9429

UniProt

 Q9UNQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNQ0

Antibodypedia

 ABCG2 antibodies

PROTEIN BROWSER
ABCG2-001
ABCG2-002
ABCG2-003
ABCG2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCG2-001
ENSP00000237612
ENST00000237612
Q9UNQ0 [Direct mapping]
ATP-binding cassette sub-family G member 2
A0A024RDD4 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family G (WHITE), member 2, isoform CRA_a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0031966 [mitochondrial membrane]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042803 [protein homodimerization activity]
GO:0042908 [xenobiotic transport]
GO:0044281 [small molecule metabolic process]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
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 655 aa
72.3 kDa 		No 6
ABCG2-002
ENSP00000426917
ENST00000515655
Q9UNQ0 [Direct mapping]
ATP-binding cassette sub-family G member 2
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006855 [drug transmembrane transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0008559 [xenobiotic-transporting ATPase activity]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0031966 [mitochondrial membrane]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042803 [protein homodimerization activity]
GO:0042908 [xenobiotic transport]
GO:0044281 [small molecule metabolic process]
GO:0046415 [urate metabolic process]
GO:0055085 [transmembrane transport]
Show all
 611 aa
67.5 kDa 		No 6
ABCG2-003
ENSP00000426916
ENST00000505480
H0YAF1 [Direct mapping]
ATP-binding cassette sub-family G member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 150 aa
15.9 kDa 		No 0
ABCG2-004
ENSP00000426934
ENST00000503830
H0YAF3 [Direct mapping]
ATP-binding cassette sub-family G member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.