Cell atlas - HS1BP3 - The Human Protein Atlas

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HS1BP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	HS1BP3
Gene description	HCLS1 binding protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035050
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the cytosol.

Main location

Nucleoli (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035050	A-431	Nucleoli	Spatial
	HPA035050	A-431	Cytosol	Spatial
	HPA035050	U-2 OS	Nucleoli	Spatial
	HPA035050	U-2 OS	Cytosol	Spatial
	HPA035050	U-251 MG	Nucleoli	Spatial
	HPA035050	U-251 MG	Cytosol	Spatial

GENE INFORMATION
Gene name	HS1BP3 (HGNC Symbol)
Synonyms	FLJ14249, HS1-BP3
Description	HCLS1 binding protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p24.1
Chromosome location (bp)	20560448 - 20651089
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118960 (version 83.38)
Entrez gene	64342
UniProt	Q53T59 (UniProt - Evidence at protein level)
neXtProt	NX_Q53T59
Antibodypedia	HS1BP3 antibodies

PROTEIN BROWSER

HS1BP3-001	HS1BP3-002	HS1BP3-003	HS1BP3-004	HS1BP3-005	HS1BP3-006	HS1BP3-007	HS1BP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS1BP3-001 ENSP00000305193 ENST00000304031	Q53T59 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0035091 [phosphatidylinositol binding] GO:0042981 [regulation of apoptotic process] Show all	392 aa 42.8 kDa	No	0
HS1BP3-002 ENSP00000385788 ENST00000406618	B5MC96 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	199 aa 21.9 kDa	No	0
HS1BP3-003 ENSP00000384984 ENST00000402541	F6TR53 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	213 aa 23.6 kDa	No	0
HS1BP3-004 ENSP00000397546 ENST00000445102	H7C0Y9 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11.7 kDa	No	0
HS1BP3-005 ENSP00000392203 ENST00000458740	H7BZZ1 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.2 kDa	No	0
HS1BP3-006 ENSP00000389960 ENST00000446825	F8WDN8 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.2 kDa	No	0
HS1BP3-007 ENSP00000387364 ENST00000415264	H7BZ19 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 7.6 kDa	No	0
HS1BP3-201 ENSP00000486756 ENST00000631166	F8WDN8 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.