Expression of HS1BP3 in cancer - Summary - The Human Protein Atlas

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HS1BP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HS1BP3
Gene description	HCLS1 binding protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035050
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035050

GENE INFORMATION
Gene name	HS1BP3 (HGNC Symbol)
Synonyms	FLJ14249, HS1-BP3
Description	HCLS1 binding protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p24.1
Chromosome location (bp)	20560448 - 20651089
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118960 (version 83.38)
Entrez gene	64342
UniProt	Q53T59 (UniProt - Evidence at protein level)
neXtProt	NX_Q53T59
Antibodypedia	HS1BP3 antibodies

PROTEIN BROWSER

HS1BP3-001	HS1BP3-002	HS1BP3-003	HS1BP3-004	HS1BP3-005	HS1BP3-006	HS1BP3-007	HS1BP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS1BP3-001 ENSP00000305193 ENST00000304031	Q53T59 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0035091 [phosphatidylinositol binding] GO:0042981 [regulation of apoptotic process] Show all	392 aa 42.8 kDa	No	0
HS1BP3-002 ENSP00000385788 ENST00000406618	B5MC96 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	199 aa 21.9 kDa	No	0
HS1BP3-003 ENSP00000384984 ENST00000402541	F6TR53 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	213 aa 23.6 kDa	No	0
HS1BP3-004 ENSP00000397546 ENST00000445102	H7C0Y9 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11.7 kDa	No	0
HS1BP3-005 ENSP00000392203 ENST00000458740	H7BZZ1 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.2 kDa	No	0
HS1BP3-006 ENSP00000389960 ENST00000446825	F8WDN8 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.2 kDa	No	0
HS1BP3-007 ENSP00000387364 ENST00000415264	H7BZ19 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 7.6 kDa	No	0
HS1BP3-201 ENSP00000486756 ENST00000631166	F8WDN8 [Direct mapping] HCLS1-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.