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CCND2

GENERAL INFORMATION

Gene name

 CCND2

Gene description

 Cyclin D2

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, HDLM-2, Karpas-707, RH-30)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049138
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and pancreatic cancer (favourable).
Thyroid cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA049138

GENE INFORMATION

Gene name

 CCND2

Synonyms

Description

 Cyclin D2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 4273772 - 4305350

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118971 (version 83.38)

Entrez gene

 894

UniProt

 P30279 (UniProt - Evidence at protein level)

neXtProt

 NX_P30279

Antibodypedia

 CCND2 antibodies

PROTEIN BROWSER
CCND2-001
CCND2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCND2-001
ENSP00000261254
ENST00000261254
P30279 [Direct mapping]
G1/S-specific cyclin-D2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000785 [chromatin]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
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 289 aa
33.1 kDa 		No 0
CCND2-004
ENSP00000442807
ENST00000536537
H0YGD4 [Direct mapping]
G1/S-specific cyclin-D2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
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GO:0007049 [cell cycle]
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 170 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.