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SATB2

GENERAL INFORMATION

Gene name

 SATB2

Gene description

 SATB homeobox 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (cerebral cortex, colon, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in large intestine and subsets of neuronal cells in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 8 antibodies.
HPA001042 , HPA029543 , CAB023669 , CAB062562 , CAB067751 , CAB068229 , CAB068230 , CAB068231
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001042
HPA029543
CAB023669
CAB062562
CAB067751
CAB068229
CAB068230
CAB068231

GENE INFORMATION

Gene name

 SATB2 (HGNC Symbol)

Synonyms

 FLJ21474, KIAA1034

Description

 SATB homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 199269500 - 199471266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119042 (version 83.38)

Entrez gene

 23314

UniProt

 Q9UPW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPW6

Antibodypedia

 SATB2 antibodies

PROTEIN BROWSER
SATB2-001
SATB2-002
SATB2-003
SATB2-007
SATB2-010
SATB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SATB2-001
ENSP00000401112
ENST00000417098
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001764 [neuron migration]
GO:0002076 [osteoblast development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009880 [embryonic pattern specification]
GO:0010468 [regulation of gene expression]
GO:0016363 [nuclear matrix]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0071310 [cellular response to organic substance]
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 733 aa
82.6 kDa 		No 0
SATB2-002
ENSP00000405420
ENST00000457245
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
 733 aa
82.6 kDa 		No 0
SATB2-003
ENSP00000260926
ENST00000260926
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
 733 aa
82.6 kDa 		No 0
SATB2-007
ENSP00000388581
ENST00000428695
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
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 615 aa
69.1 kDa 		No 0
SATB2-010
ENSP00000388764
ENST00000443023
C9JR56 [Direct mapping]
DNA-binding protein SATB
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
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 674 aa
76 kDa 		No 0
SATB2-201
ENSP00000483287
ENST00000614512
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
 615 aa
69.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.