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TJP2

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GENERAL INFORMATION

Gene name

 TJP2

Gene description

 Tight junction protein 2

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, cytosol & cell junctions.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cell Junctions (validated), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA001813 , CAB009228
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, cytosol & cell junctions.

Main location

 Plasma membrane (supported), Cell Junctions (validated), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001813 A-431 Plasma membrane
Cell Junctions
Cytosol
HPA001813 U-2 OS Plasma membrane
Cell Junctions
Cytosol
HPA001813 U-251 MG Plasma membrane
Cell Junctions
Cytosol
CAB009228 A-431 Plasma membrane
Cell Junctions
Cytosol
CAB009228 U-2 OS Plasma membrane
Cell Junctions
CAB009228 U-251 MG Plasma membrane
Cell Junctions

GENE INFORMATION

Gene name

 TJP2 (HGNC Symbol)

Synonyms

 DFNA51, X104, ZO-2, ZO2

Description

 Tight junction protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 9

Cytoband

 q21.11

Chromosome location (bp)

 69121264 - 69255208

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119139 (version 83.38)

Entrez gene

 9414

UniProt

 Q9UDY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UDY2

Antibodypedia

 TJP2 antibodies

PROTEIN BROWSER
TJP2-001
TJP2-002
TJP2-003
TJP2-004
TJP2-006
TJP2-007
TJP2-201
TJP2-202
TJP2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TJP2-001
ENSP00000402941
ENST00000423935
B1AN86 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
Show all
 161 aa
17.9 kDa 		No 0
TJP2-002
ENSP00000366469
ENST00000377259
B1AN85 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 101 aa
10.9 kDa 		No 0
TJP2-003
ENSP00000366453
ENST00000377245
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1190 aa
134 kDa 		No 0
TJP2-004
ENSP00000265384
ENST00000265384
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 993 aa
111.7 kDa 		No 0
TJP2-006
ENSP00000345893
ENST00000348208
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1043 aa
117.8 kDa 		No 0
TJP2-007
ENSP00000475926
ENST00000606364
U3KQJ2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
Show all
 134 aa
14.8 kDa 		No 0
TJP2-201
ENSP00000392178
ENST00000453658
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1020 aa
115.2 kDa 		No 0
TJP2-202
ENSP00000442090
ENST00000535702
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1157 aa
130.4 kDa 		No 0
TJP2-203
ENSP00000438262
ENST00000539225
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008022 [protein C-terminus binding]
GO:0010033 [response to organic substance]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1221 aa
137.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.