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TJP2

GENERAL INFORMATION

Gene name

 TJP2

Gene description

 Tight junction protein 2

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001813 , CAB009228
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001813
CAB009228

GENE INFORMATION

Gene name

 TJP2 (HGNC Symbol)

Synonyms

 DFNA51, X104, ZO-2, ZO2

Description

 Tight junction protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 9

Cytoband

 q21.11

Chromosome location (bp)

 69121264 - 69255208

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119139 (version 83.38)

Entrez gene

 9414

UniProt

 Q9UDY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UDY2

Antibodypedia

 TJP2 antibodies

PROTEIN BROWSER
TJP2-001
TJP2-002
TJP2-003
TJP2-004
TJP2-006
TJP2-007
TJP2-201
TJP2-202
TJP2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TJP2-001
ENSP00000402941
ENST00000423935
B1AN86 [Direct mapping]
Tight junction protein ZO-2
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
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 161 aa
17.9 kDa 		No 0
TJP2-002
ENSP00000366469
ENST00000377259
B1AN85 [Direct mapping]
Tight junction protein ZO-2
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 101 aa
10.9 kDa 		No 0
TJP2-003
ENSP00000366453
ENST00000377245
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
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 1190 aa
134 kDa 		No 0
TJP2-004
ENSP00000265384
ENST00000265384
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 993 aa
111.7 kDa 		No 0
TJP2-006
ENSP00000345893
ENST00000348208
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1043 aa
117.8 kDa 		No 0
TJP2-007
ENSP00000475926
ENST00000606364
U3KQJ2 [Direct mapping]
Tight junction protein ZO-2
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
Show all
 134 aa
14.8 kDa 		No 0
TJP2-201
ENSP00000392178
ENST00000453658
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1020 aa
115.2 kDa 		No 0
TJP2-202
ENSP00000442090
ENST00000535702
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1157 aa
130.4 kDa 		No 0
TJP2-203
ENSP00000438262
ENST00000539225
Q9UDY2 [Direct mapping]
Tight junction protein ZO-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008022 [protein C-terminus binding]
GO:0010033 [response to organic substance]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030674 [protein binding, bridging]
GO:0035329 [hippo signaling]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0050892 [intestinal absorption]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0090559 [regulation of membrane permeability]
Show all
 1221 aa
137.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.