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SENP5

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GENERAL INFORMATION

Gene name

 SENP5

Gene description

 SUMO1/sentrin specific peptidase 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SENP5 (HGNC Symbol)

Synonyms

 MGC27076

Description

 SUMO1/sentrin specific peptidase 5 (HGNC Symbol)

Entrez gene summary

 The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 196867856 - 196934714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119231 (version 83.38)

Entrez gene

 205564

UniProt

 Q96HI0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HI0

Antibodypedia

 SENP5 antibodies

PROTEIN BROWSER
SENP5-001
SENP5-002
SENP5-003
SENP5-005
SENP5-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SENP5-001
ENSP00000327197
ENST00000323460
Q96HI0 [Direct mapping]
Sentrin-specific protease 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0007049 [cell cycle]
GO:0008234 [cysteine-type peptidase activity]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051301 [cell division]
Show all
 755 aa
86.7 kDa 		No 0
SENP5-002
ENSP00000390231
ENST00000445299
Q96HI0 [Direct mapping]
Sentrin-specific protease 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0007049 [cell cycle]
GO:0008234 [cysteine-type peptidase activity]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051301 [cell division]
Show all
 709 aa
81.3 kDa 		No 0
SENP5-003
ENSP00000396927
ENST00000419026
C9JHT8 [Direct mapping]
SUMO1/sentrin specific peptidase 5, isoform CRA_a; Sentrin-specific protease 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
Show all
 245 aa
29.3 kDa 		No 0
SENP5-005
ENSP00000405663
ENST00000448068
H7C2F8 [Direct mapping]
Sentrin-specific protease 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
Show all
 98 aa
11.5 kDa 		No 0
SENP5-006
ENSP00000415227
ENST00000434433
H7C424 [Direct mapping]
Sentrin-specific protease 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
Show all
 77 aa
9.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.