Tissue expression of SENP5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SENP5
Gene description	SUMO1/sentrin specific peptidase 5
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SENP5 (HGNC Symbol)
Synonyms	MGC27076
Description	SUMO1/sentrin specific peptidase 5 (HGNC Symbol)
Entrez gene summary	The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	196867856 - 196934714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119231 (version 83.38)
Entrez gene	205564
UniProt	Q96HI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HI0
Antibodypedia	SENP5 antibodies

PROTEIN BROWSER

SENP5-001	SENP5-002	SENP5-003	SENP5-005	SENP5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SENP5-001 ENSP00000327197 ENST00000323460	Q96HI0 [Direct mapping] Sentrin-specific protease 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006508 [proteolysis] GO:0007049 [cell cycle] GO:0008234 [cysteine-type peptidase activity] GO:0016925 [protein sumoylation] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051301 [cell division] Show all	755 aa 86.7 kDa	No	0
SENP5-002 ENSP00000390231 ENST00000445299	Q96HI0 [Direct mapping] Sentrin-specific protease 5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006508 [proteolysis] GO:0007049 [cell cycle] GO:0008234 [cysteine-type peptidase activity] GO:0016925 [protein sumoylation] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051301 [cell division] Show all	709 aa 81.3 kDa	No	0
SENP5-003 ENSP00000396927 ENST00000419026	C9JHT8 [Direct mapping] SUMO1/sentrin specific peptidase 5, isoform CRA_a; Sentrin-specific protease 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	245 aa 29.3 kDa	No	0
SENP5-005 ENSP00000405663 ENST00000448068	H7C2F8 [Direct mapping] Sentrin-specific protease 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	98 aa 11.5 kDa	No	0
SENP5-006 ENSP00000415227 ENST00000434433	H7C424 [Direct mapping] Sentrin-specific protease 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	77 aa 9.1 kDa	No	0