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RAD23B

GENERAL INFORMATION

Gene name

 RAD23B

Gene description

 RAD23 homolog B, nucleotide excision repair protein

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA029718 , HPA029720 , CAB033868
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and lung cancer (unfavourable).
Head and neck cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029718
HPA029720
CAB033868

GENE INFORMATION

Gene name

 RAD23B (HGNC Symbol)

Synonyms

 HHR23B, HR23B, P58

Description

 RAD23 homolog B, nucleotide excision repair protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Chromosome

 9

Cytoband

 q31.2

Chromosome location (bp)

 107283137 - 107332194

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119318 (version 83.38)

Entrez gene

 5887

UniProt

 P54727 (UniProt - Evidence at protein level)

neXtProt

 NX_P54727

Antibodypedia

 RAD23B antibodies

PROTEIN BROWSER
RAD23B-001
RAD23B-002
RAD23B-003
RAD23B-004
RAD23B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAD23B-001
ENSP00000350708
ENST00000358015
P54727 [Direct mapping]
UV excision repair protein RAD23 homolog B
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007283 [spermatogenesis]
GO:0031593 [polyubiquitin binding]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048568 [embryonic organ development]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071942 [XPC complex]
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 409 aa
43.2 kDa 		No 0
RAD23B-002
ENSP00000416868
ENST00000419616
Q5W0S5 [Direct mapping]
UV excision repair protein RAD23 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 146 aa
15.2 kDa 		No 0
RAD23B-003
ENSP00000415821
ENST00000442587
Q5W0S4 [Direct mapping]
UV excision repair protein RAD23 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 80 aa
8.5 kDa 		No 0
RAD23B-004
ENSP00000396975
ENST00000457811
H0Y579 [Direct mapping]
UV excision repair protein RAD23 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 114 aa
12.1 kDa 		No 0
RAD23B-201
ENSP00000405623
ENST00000416373
P54727 [Direct mapping]
UV excision repair protein RAD23 homolog B
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0031593 [polyubiquitin binding]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071942 [XPC complex]
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 337 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.