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RAD23 homolog B, nucleotide excision repair protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
P54727 [Direct mapping] UV excision repair protein RAD23 homolog B
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex] GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0007283 [spermatogenesis] GO:0031593 [polyubiquitin binding] GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048568 [embryonic organ development] GO:0070911 [global genome nucleotide-excision repair] GO:0071942 [XPC complex]
P54727 [Direct mapping] UV excision repair protein RAD23 homolog B
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex] GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0003684 [damaged DNA binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0031593 [polyubiquitin binding] GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0070911 [global genome nucleotide-excision repair] GO:0071942 [XPC complex]
