Expression of FKBP15 in cancer - Summary - The Human Protein Atlas

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FKBP15

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FKBP15
Gene description	FK506 binding protein 15, 133kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA007979
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (unfavourable).
Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007979

GENE INFORMATION
Gene name	FKBP15 (HGNC Symbol)
Synonyms	FKBP133, KIAA0674, PPP1R76, WAFL
Description	FK506 binding protein 15, 133kDa (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q32
Chromosome location (bp)	113161006 - 113221361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119321 (version 83.38)
Entrez gene	23307
UniProt	Q5T1M5 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T1M5
Antibodypedia	FKBP15 antibodies

PROTEIN BROWSER

FKBP15-001	FKBP15-002	FKBP15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP15-001 ENSP00000416158 ENST00000446284	A0A0A0MT60 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	1244 aa 136.3 kDa	No	0
FKBP15-002 ENSP00000415733 ENST00000414250	X6RKW4 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	497 aa 53 kDa	No	0
FKBP15-201 ENSP00000238256 ENST00000238256	Q5T1M5 [Direct mapping] FK506-binding protein 15 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005884 [actin filament] GO:0006457 [protein folding] GO:0006897 [endocytosis] GO:0010923 [negative regulation of phosphatase activity] GO:0016020 [membrane] GO:0030424 [axon] GO:0030426 [growth cone] Show all	1219 aa 133.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.