Expression of BSPRY in cancer - Summary - The Human Protein Atlas

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BSPRY

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BSPRY
Gene description	B-box and SPRY domain containing
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, MCF7, T-47d)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042889
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA042889

GENE INFORMATION
Gene name	BSPRY (HGNC Symbol)
Synonyms	FLJ20150
Description	B-box and SPRY domain containing (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q32
Chromosome location (bp)	113349541 - 113371233
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119411 (version 83.38)
Entrez gene	54836
UniProt	Q5W0U4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5W0U4
Antibodypedia	BSPRY antibodies

PROTEIN BROWSER

BSPRY-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BSPRY-001 ENSP00000363298 ENST00000374183	Q5W0U4 [Direct mapping] B box and SPRY domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006816 [calcium ion transport] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0031252 [cell leading edge] GO:0048471 [perinuclear region of cytoplasm] Show all	402 aa 44.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.