Expression of NRDE2 in cancer - Summary - The Human Protein Atlas

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NRDE2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NRDE2
Gene description	NRDE-2, necessary for RNA interference, domain containing
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA047050 , HPA050583
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047050	HPA050583

GENE INFORMATION
Gene name	NRDE2 (HGNC Symbol)
Synonyms	C14orf102, FLJ14051
Description	NRDE-2, necessary for RNA interference, domain containing (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.11
Chromosome location (bp)	90267856 - 90332137
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119720 (version 83.38)
Entrez gene	55051
UniProt	Q9H7Z3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H7Z3
Antibodypedia	NRDE2 antibodies

PROTEIN BROWSER

NRDE2-001	NRDE2-007	NRDE2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRDE2-001 ENSP00000346335 ENST00000354366	Q9H7Z3 [Direct mapping] Protein NRDE2 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	1164 aa 132.7 kDa	No	0
NRDE2-007 ENSP00000452071 ENST00000554464	H0YJT0 [Direct mapping] Protein NRDE2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		204 aa 23.6 kDa	No	0
NRDE2-201 ENSP00000486385 ENST00000628832	G3V338 [Direct mapping] Protein NRDE2 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.