Expression of PYROXD2 in cancer - Summary - The Human Protein Atlas

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PYROXD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PYROXD2
Gene description	Pyridine nucleotide-disulphide oxidoreductase domain 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-937)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA037566 , HPA037567
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and glioma (unfavourable).
Urothelial cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037566	HPA037567

GENE INFORMATION
Gene name	PYROXD2 (HGNC Symbol)
Synonyms	C10orf33, FLJ23849
Description	Pyridine nucleotide-disulphide oxidoreductase domain 2 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q24.2
Chromosome location (bp)	98383565 - 98415184
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119943 (version 83.38)
Entrez gene	84795
UniProt	Q8N2H3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N2H3
Antibodypedia	PYROXD2 antibodies

PROTEIN BROWSER

PYROXD2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PYROXD2-001 ENSP00000359607 ENST00000370575	Q8N2H3 [Direct mapping] Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	581 aa 63.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.