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CD274

GENERAL INFORMATION

Gene name

 CD274

Gene description

 CD274 molecule

Protein class

 Cancer-related genes
CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HDLM-2, U-251 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and breast cancer (favourable).
Colorectal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CD274 (HGNC Symbol)

Synonyms

 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Description

 CD274 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 5450503 - 5470566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120217 (version 83.38)

Entrez gene

 29126

UniProt

 Q9NZQ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZQ7

Antibodypedia

 CD274 antibodies

PROTEIN BROWSER
CD274-001
CD274-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD274-001
ENSP00000370989
ENST00000381577
Q9NZQ7 [Direct mapping]
Programmed cell death 1 ligand 1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0030335 [positive regulation of cell migration]
GO:0031295 [T cell costimulation]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0034097 [response to cytokine]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
GO:1903556 [negative regulation of tumor necrosis factor superfamily cytokine production]
GO:2001181 [positive regulation of interleukin-10 secretion]
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 290 aa
33.3 kDa 		Yes 1
CD274-201
ENSP00000370985
ENST00000381573
Q9NZQ7 [Direct mapping]
Programmed cell death 1 ligand 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0034097 [response to cytokine]
GO:0042102 [positive regulation of T cell proliferation]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0070062 [extracellular exosome]
GO:1903556 [negative regulation of tumor necrosis factor superfamily cytokine production]
GO:2001181 [positive regulation of interleukin-10 secretion]
Show all
 176 aa
20.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.