Tissue expression of CD274 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD274
Gene description	CD274 molecule
Protein class	Cancer-related genes CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	CD274 (HGNC Symbol)
Synonyms	B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
Description	CD274 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	5450503 - 5470566
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120217 (version 83.38)
Entrez gene	29126
UniProt	Q9NZQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZQ7
Antibodypedia	CD274 antibodies

PROTEIN BROWSER

CD274-001	CD274-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD274-001 ENSP00000370989 ENST00000381577	Q9NZQ7 [Direct mapping] Programmed cell death 1 ligand 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0032689 [negative regulation of interferon-gamma production] GO:0032693 [negative regulation of interleukin-10 production] GO:0034097 [response to cytokine] GO:0042102 [positive regulation of T cell proliferation] GO:0042130 [negative regulation of T cell proliferation] GO:0046007 [negative regulation of activated T cell proliferation] GO:0070062 [extracellular exosome] GO:1901998 [toxin transport] GO:1903556 [negative regulation of tumor necrosis factor superfamily cytokine production] GO:2001181 [positive regulation of interleukin-10 secretion] Show all	290 aa 33.3 kDa	Yes	1
CD274-201 ENSP00000370985 ENST00000381573	Q9NZQ7 [Direct mapping] Programmed cell death 1 ligand 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0032689 [negative regulation of interferon-gamma production] GO:0032693 [negative regulation of interleukin-10 production] GO:0034097 [response to cytokine] GO:0042102 [positive regulation of T cell proliferation] GO:0046007 [negative regulation of activated T cell proliferation] GO:0070062 [extracellular exosome] GO:1903556 [negative regulation of tumor necrosis factor superfamily cytokine production] GO:2001181 [positive regulation of interleukin-10 secretion] Show all	176 aa 20.2 kDa	No	1