Expression of PCMT1 in cancer - Summary - The Human Protein Atlas

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PCMT1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCMT1
Gene description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003239
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable), head and neck cancer (unfavourable), liver cancer (unfavourable), endometrial cancer (unfavourable), urothelial cancer (unfavourable) and cervical cancer (unfavourable).
Breast cancer p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003239

GENE INFORMATION
Gene name	PCMT1
Synonyms
Description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	149749443 - 149811420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120265 (version 83.38)
Entrez gene	5110
UniProt	P22061 (UniProt - Evidence at protein level)
neXtProt	NX_P22061
Antibodypedia	PCMT1 antibodies

PROTEIN BROWSER

PCMT1-001	PCMT1-002	PCMT1-004	PCMT1-008	PCMT1-201	PCMT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCMT1-001 ENSP00000356354 ENST00000367384	H7BY58 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	286 aa 30.4 kDa	No	1
PCMT1-002 ENSP00000420813 ENST00000464889	A0A0A0MRJ6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	285 aa 30.3 kDa	No	1
PCMT1-004 ENSP00000356348 ENST00000367378	A0A0A0MRJ6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	285 aa 30.3 kDa	No	1
PCMT1-008 ENSP00000418881 ENST00000495487	C9J0F2 [Direct mapping] Protein-L-isoaspartate(D-aspartate) O-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	96 aa 10.4 kDa	No	0
PCMT1-201 ENSP00000356350 ENST00000367380	P22061 [Direct mapping] Protein-L-isoaspartate(D-aspartate) O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] GO:0030091 [protein repair] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	250 aa 26.4 kDa	No	1
PCMT1-202 ENSP00000438247 ENST00000544496	F6S8N6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	250 aa 26.6 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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