Tissue expression of PCMT1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PCMT1

TISSUE

premium

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PCMT1
Gene description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003239
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

N/A

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PCMT1
Synonyms
Description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	149749443 - 149811420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120265 (version 83.38)
Entrez gene	5110
UniProt	P22061 (UniProt - Evidence at protein level)
neXtProt	NX_P22061
Antibodypedia	PCMT1 antibodies

PROTEIN BROWSER

PCMT1-001	PCMT1-002	PCMT1-004	PCMT1-008	PCMT1-201	PCMT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCMT1-001 ENSP00000356354 ENST00000367384	H7BY58 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	286 aa 30.4 kDa	No	1
PCMT1-002 ENSP00000420813 ENST00000464889	A0A0A0MRJ6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	285 aa 30.3 kDa	No	1
PCMT1-004 ENSP00000356348 ENST00000367378	A0A0A0MRJ6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	285 aa 30.3 kDa	No	1
PCMT1-008 ENSP00000418881 ENST00000495487	C9J0F2 [Direct mapping] Protein-L-isoaspartate(D-aspartate) O-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	96 aa 10.4 kDa	No	0
PCMT1-201 ENSP00000356350 ENST00000367380	P22061 [Direct mapping] Protein-L-isoaspartate(D-aspartate) O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] GO:0030091 [protein repair] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	250 aa 26.4 kDa	No	1
PCMT1-202 ENSP00000438247 ENST00000544496	F6S8N6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	250 aa 26.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.