Tissue expression of TNN - Summary - The Human Protein Atlas

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TNN

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TNN
Gene description	Tenascin N
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue)
GTEx:	Group enriched (adipose tissue, breast, pituitary gland, salivary gland, skin, thyroid gland)
FANTOM5:	Tissue enhanced (breast, gallbladder, retina)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 3 antibodies. HPA026726 , HPA026764 , CAB010907
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adipose tissue, breast, pituitary gland, salivary gland, skin, thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (breast, gallbladder, retina)

GENE INFORMATION
Gene name	TNN
Synonyms
Description	Tenascin N (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	175067858 - 175148066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120332 (version 83.38)
Entrez gene	63923
UniProt	Q9UQP3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQP3
Antibodypedia	TNN antibodies

PROTEIN BROWSER

TNN-001	TNN-201	TNN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNN-001 ENSP00000239462 ENST00000239462	Q9UQP3 [Direct mapping] Tenascin-N A0A0A6YY94 [Direct mapping] Tenascin-N Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005578 [proteinaceous extracellular matrix] GO:0007160 [cell-matrix adhesion] GO:0007409 [axonogenesis] GO:0009986 [cell surface] GO:0016049 [cell growth] GO:0016477 [cell migration] GO:0042802 [identical protein binding] Show all	1299 aa 144 kDa	Yes	0
TNN-201 ENSP00000480895 ENST00000621086	A0A087WXC4 [Direct mapping] Tenascin-N Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1122 aa 124.5 kDa	Yes	0
TNN-202 ENSP00000481259 ENST00000622870	A0A087WXT0 [Direct mapping] Tenascin-N Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1122 aa 124.4 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.