Cell atlas - ACAT2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ACAT2

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ACAT2
Gene description	Acetyl-CoA acetyltransferase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA025736
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleus.

Main location

Cytosol (supported)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA025736	A-431	Nucleus
			Nucleoli
			Cytosol
	HPA025736	U-2 OS	Nucleoplasm
	HPA025736	U-2 OS	Cytosol
	HPA025736	U-251 MG	Nucleoplasm
	HPA025736	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ACAT2
Synonyms
Description	Acetyl-CoA acetyltransferase 2 (HGNC Symbol)
Entrez gene summary	The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	159760328 - 159779055
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120437 (version 83.38)
Entrez gene	39
UniProt	Q9BWD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWD1
Antibodypedia	ACAT2 antibodies

PROTEIN BROWSER

ACAT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAT2-001 ENSP00000356015 ENST00000367048	Q9BWD1 [Direct mapping] Acetyl-CoA acetyltransferase, cytosolic Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003985 [acetyl-CoA C-acetyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0070062 [extracellular exosome] Show all	397 aa 41.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.