Fields »
ABOUT
HELP
BLOG
ACAT2

GENERAL INFORMATION

Gene name

 ACAT2

Gene description

 Acetyl-CoA acetyltransferase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression at variable levels in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA025736 , HPA025765 , HPA025811 , CAB021106
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable), endometrial cancer (unfavourable) and renal cancer (unfavourable).
Colorectal cancer p<0.001
Endometrial cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA025736
HPA025765
HPA025811
CAB021106

GENE INFORMATION

Gene name

 ACAT2

Synonyms

Description

 Acetyl-CoA acetyltransferase 2 (HGNC Symbol)

Entrez gene summary

 The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 159760328 - 159779055

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120437 (version 83.38)

Entrez gene

 39

UniProt

 Q9BWD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWD1

Antibodypedia

 ACAT2 antibodies

PROTEIN BROWSER
ACAT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACAT2-001
ENSP00000356015
ENST00000367048
Q9BWD1 [Direct mapping]
Acetyl-CoA acetyltransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003985 [acetyl-CoA C-acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0070062 [extracellular exosome]
Show all
 397 aa
41.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.