Fields »
ABOUT
HELP
BLOG
ALG5

GENERAL INFORMATION

Gene name

 ALG5

Gene description

 ALG5, dolichyl-phosphate beta-glucosyltransferase

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, including immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA007989
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALG5 (HGNC Symbol)

Synonyms

 bA421P11.2

Description

 ALG5, dolichyl-phosphate beta-glucosyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 36949775 - 37000261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120697 (version 83.38)

Entrez gene

 29880

UniProt

 Q9Y673 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y673

Antibodypedia

 ALG5 antibodies

PROTEIN BROWSER
ALG5-001
ALG5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALG5-001
ENSP00000239891
ENST00000239891
Q9Y673 [Direct mapping]
Dolichyl-phosphate beta-glucosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity]
GO:0004576 [oligosaccharyl transferase activity]
GO:0004581 [dolichyl-phosphate beta-glucosyltransferase activity]
GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006486 [protein glycosylation]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006506 [GPI anchor biosynthetic process]
GO:0007368 [determination of left/right symmetry]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019348 [dolichol metabolic process]
GO:0035269 [protein O-linked mannosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 324 aa
36.9 kDa 		Yes 0
ALG5-201
ENSP00000390533
ENST00000443765
Q9Y673 [Direct mapping]
Dolichyl-phosphate beta-glucosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity]
GO:0004576 [oligosaccharyl transferase activity]
GO:0004581 [dolichyl-phosphate beta-glucosyltransferase activity]
GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006486 [protein glycosylation]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019348 [dolichol metabolic process]
GO:0035269 [protein O-linked mannosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 294 aa
33.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.