Cell atlas - TGFBI - The Human Protein Atlas

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TGFBI

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	TGFBI
Gene description	Transforming growth factor, beta-induced, 68kDa
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (U-87 MG, LHCN-M2, U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008612
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, LHCN-M2, U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008612	A-431	Cytosol
	HPA008612	U-2 OS	Cytosol
	HPA008612	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TGFBI (HGNC Symbol)
Synonyms	BIGH3, CDB1, CDGG1, CSD1, CSD2, CSD3, LCD1
Description	Transforming growth factor, beta-induced, 68kDa (HGNC Symbol)
Entrez gene summary	This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	136028895 - 136063818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120708 (version 83.38)
Entrez gene	7045
UniProt	Q15582 (UniProt - Evidence at protein level)
neXtProt	NX_Q15582
Antibodypedia	TGFBI antibodies

PROTEIN BROWSER

TGFBI-001	TGFBI-008	TGFBI-012	TGFBI-016	TGFBI-017	TGFBI-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGFBI-001 ENSP00000416330 ENST00000442011	Q15582 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007162 [negative regulation of cell adhesion] GO:0007601 [visual perception] GO:0008283 [cell proliferation] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0050840 [extracellular matrix binding] GO:0050896 [response to stimulus] GO:0070062 [extracellular exosome] Show all	683 aa 74.7 kDa	Yes	0
TGFBI-008 ENSP00000421440 ENST00000514554	H0Y8L3 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] Show all	366 aa 39.8 kDa	No	0
TGFBI-012 ENSP00000423871 ENST00000508767	H0Y9D7 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] Show all	194 aa 21.1 kDa	No	0
TGFBI-016 ENSP00000423935 ENST00000508076	D6RBX4 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] Show all	65 aa 7.3 kDa	No	0
TGFBI-017 ENSP00000427137 ENST00000503087	H0YAH8 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] Show all	78 aa 8.4 kDa	No	0
TGFBI-019 ENSP00000474155 ENST00000604555	S4R3C6 [Direct mapping] Transforming growth factor-beta-induced protein ig-h3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0030198 [extracellular matrix organization] Show all	219 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.