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TGFBI

GENERAL INFORMATION

Gene name

 TGFBI

Gene description

 Transforming growth factor, beta-induced, 68kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (LHCN-M2, U-2197, U-87 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in extracellular fibers and connective tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA008612 , HPA017019
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable), ovarian cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Ovarian cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008612
HPA017019

GENE INFORMATION

Gene name

 TGFBI (HGNC Symbol)

Synonyms

 BIGH3, CDB1, CDGG1, CSD1, CSD2, CSD3, LCD1

Description

 Transforming growth factor, beta-induced, 68kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 136028895 - 136063818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120708 (version 83.38)

Entrez gene

 7045

UniProt

 Q15582 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15582

Antibodypedia

 TGFBI antibodies

PROTEIN BROWSER
TGFBI-001
TGFBI-008
TGFBI-012
TGFBI-016
TGFBI-017
TGFBI-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TGFBI-001
ENSP00000416330
ENST00000442011
Q15582 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0002062 [chondrocyte differentiation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007601 [visual perception]
GO:0008283 [cell proliferation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0044267 [cellular protein metabolic process]
GO:0050840 [extracellular matrix binding]
GO:0050896 [response to stimulus]
GO:0070062 [extracellular exosome]
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 683 aa
74.7 kDa 		Yes 0
TGFBI-008
ENSP00000421440
ENST00000514554
H0Y8L3 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0030198 [extracellular matrix organization]
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 366 aa
39.8 kDa 		No 0
TGFBI-012
ENSP00000423871
ENST00000508767
H0Y9D7 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0030198 [extracellular matrix organization]
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 194 aa
21.1 kDa 		No 0
TGFBI-016
ENSP00000423935
ENST00000508076
D6RBX4 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0030198 [extracellular matrix organization]
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 65 aa
7.3 kDa 		No 0
TGFBI-017
ENSP00000427137
ENST00000503087
H0YAH8 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0030198 [extracellular matrix organization]
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 78 aa
8.4 kDa 		No 0
TGFBI-019
ENSP00000474155
ENST00000604555
S4R3C6 [Direct mapping]
Transforming growth factor-beta-induced protein ig-h3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0030198 [extracellular matrix organization]
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 219 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.