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ADRA1A

GENERAL INFORMATION

Gene name

 ADRA1A

Gene description

 Adrenoceptor alpha 1A

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (adipose tissue, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in cells and processes in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA029678 , HPA029679
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029678
HPA029679

GENE INFORMATION

Gene name

 ADRA1A (HGNC Symbol)

Synonyms

 ADRA1C, ADRA1L1

Description

 Adrenoceptor alpha 1A (HGNC Symbol)

Entrez gene summary

 Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 26748150 - 26867273

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120907 (version 83.38)

Entrez gene

 148

UniProt

 P35348 (UniProt - Evidence at protein level)

neXtProt

 NX_P35348

Antibodypedia

 ADRA1A antibodies

PROTEIN BROWSER
ADRA1A-001
ADRA1A-002
ADRA1A-003
ADRA1A-004
ADRA1A-005
ADRA1A-008
ADRA1A-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRA1A-001
ENSP00000369956
ENST00000380582
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
Show all
 429 aa
47.5 kDa 		No 7
ADRA1A-002
ENSP00000346557
ENST00000354550
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
Show all
 455 aa
50.8 kDa 		No 7
ADRA1A-003
ENSP00000276393
ENST00000276393
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
Show all
 466 aa
51.5 kDa 		No 7
ADRA1A-004
ENSP00000369960
ENST00000380586
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
B0ZBD3 [Target identity:100%; Query identity:100%]
Adrenergic, alpha-1A-, receptor variant 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001985 [negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine]
GO:0001997 [positive regulation of the force of heart contraction by epinephrine-norepinephrine]
GO:0003084 [positive regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007512 [adult heart development]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035265 [organ growth]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060073 [micturition]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0097195 [pilomotor reflex]
Show all
 475 aa
52.2 kDa 		No 7
ADRA1A-005
ENSP00000369946
ENST00000380572
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
Show all
 342 aa
37.5 kDa 		No 6
ADRA1A-008
ENSP00000369947
ENST00000380573
P35348 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042493 [response to drug]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045760 [positive regulation of action potential]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0060402 [calcium ion transport into cytosol]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090037 [positive regulation of protein kinase C signaling]
Show all
 466 aa
51.5 kDa 		No 7
ADRA1A-009
ENSP00000430793
ENST00000519229
E7EW16 [Direct mapping]
Alpha-1A adrenergic receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 427 aa
47.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.