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NPPB

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GENERAL INFORMATION

Gene name

 NPPB

Gene description

 Natriuretic peptide B

Protein class

 Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (CACO-2, BEWO)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (CACO-2, BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NPPB

Synonyms

Description

 Natriuretic peptide B (HGNC Symbol)

Entrez gene summary

 This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 11857464 - 11858931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120937 (version 83.38)

Entrez gene

 4879

UniProt

 P16860 (UniProt - Evidence at protein level)

neXtProt

 NX_P16860

Antibodypedia

 NPPB antibodies

PROTEIN BROWSER
NPPB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPPB-001
ENSP00000365651
ENST00000376468
P16860 [Direct mapping]
Natriuretic peptides B Brain natriuretic peptide 32 BNP(1-30) BNP(1-29) BNP(1-28) BNP(2-31) BNP(3-32) BNP(3-30) BNP(3-29) BNP(4-32) BNP(4-31) BNP(4-30) BNP(4-29) BNP(4-27) BNP(5-32) BNP(5-31) BNP(5-29)
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006182 [cGMP biosynthetic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007589 [body fluid secretion]
GO:0008217 [regulation of blood pressure]
GO:0008613 [diuretic hormone activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0030308 [negative regulation of cell growth]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042312 [regulation of vasodilation]
GO:0043114 [regulation of vascular permeability]
GO:0043234 [protein complex]
GO:0050880 [regulation of blood vessel size]
Show all
 134 aa
14.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.