Tissue expression of NPPB - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPPB
Gene description	Natriuretic peptide B
Protein class	Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (heart muscle)
GTEx:	Tissue enriched (heart muscle)
FANTOM5:	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION
Gene name	NPPB
Synonyms
Description	Natriuretic peptide B (HGNC Symbol)
Entrez gene summary	This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11857464 - 11858931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120937 (version 83.38)
Entrez gene	4879
UniProt	P16860 (UniProt - Evidence at protein level)
neXtProt	NX_P16860
Antibodypedia	NPPB antibodies

PROTEIN BROWSER

NPPB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPPB-001 ENSP00000365651 ENST00000376468	P16860 [Direct mapping] Natriuretic peptides B Brain natriuretic peptide 32 BNP(1-30) BNP(1-29) BNP(1-28) BNP(2-31) BNP(3-32) BNP(3-30) BNP(3-29) BNP(4-32) BNP(4-31) BNP(4-30) BNP(4-29) BNP(4-27) BNP(5-32) BNP(5-31) BNP(5-29) Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006182 [cGMP biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007168 [receptor guanylyl cyclase signaling pathway] GO:0007589 [body fluid secretion] GO:0008217 [regulation of blood pressure] GO:0008613 [diuretic hormone activity] GO:0016525 [negative regulation of angiogenesis] GO:0030308 [negative regulation of cell growth] GO:0035810 [positive regulation of urine volume] GO:0035815 [positive regulation of renal sodium excretion] GO:0042312 [regulation of vasodilation] GO:0043114 [regulation of vascular permeability] GO:0043234 [protein complex] GO:0050880 [regulation of blood vessel size] Show all	134 aa 14.7 kDa	Yes	0