Expression of FAM117A in cancer - Summary - The Human Protein Atlas

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FAM117A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM117A
Gene description	Family with sequence similarity 117, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA022531
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), breast cancer (favourable) and pancreatic cancer (favourable).
Lung cancer p<0.001 Breast cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022531

GENE INFORMATION
Gene name	FAM117A
Synonyms
Description	Family with sequence similarity 117, member A (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	49710332 - 49789180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121104 (version 83.38)
Entrez gene	81558
UniProt	Q9C073 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C073
Antibodypedia	FAM117A antibodies

PROTEIN BROWSER

FAM117A-001	FAM117A-002	FAM117A-009	FAM117A-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM117A-001 ENSP00000240364 ENST00000240364	Q9C073 [Direct mapping] Protein FAM117A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		453 aa 48.3 kDa	No	0
FAM117A-002 ENSP00000465808 ENST00000513602	Q9C073 [Direct mapping] Protein FAM117A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 19.4 kDa	No	0
FAM117A-009 ENSP00000421412 ENST00000506156	D6RFX7 [Direct mapping] Protein FAM117A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 23.5 kDa	No	0
FAM117A-012 ENSP00000427326 ENST00000511743	D6RJ87 [Direct mapping] Protein FAM117A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 25.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.