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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCC11
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCC11

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, prostate cancer)
HPA (cell line):Cell line enriched (T-47d)
HPA (normal tissue):Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data.

Reliability score

Uncertain based on 4 antibodies.
HPA031980 , HPA031981 , HPA031982 , CAB032513
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA031980
HPA031981
HPA031982
CAB032513

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic positivity with a granular pattern was observed in most malignant cells. Several cases of cholangiocarcinomas and thyroid cancers were strongly stained. A majority of squamous cell carcinomas were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of the cancer tissues displayed moderate to strong cytoplasmic, often with a perinuclear accentuation along with additional nuclear staining in some cases. Several cases of lymphomas and renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong cytoplasmic staining in a granular pattern. Several cases of squamous cell carcinomas, lymphomas, stomach, liver and colorectal cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic staining was observed in cancer tissues.

GENE INFORMATION

Gene name

ABCC11 (HGNC Symbol)

Synonyms

MRP8

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q12.1

Chromosome location (bp)

48166910 - 48247568

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121270 (version 83.38)

Entrez gene

85320

UniProt

Q96J66 (UniProt - Evidence at protein level)

neXtProt

NX_Q96J66

Antibodypedia

ABCC11 antibodies

PROTEIN BROWSER

ABCC11-001
ABCC11-002
ABCC11-004
ABCC11-006
ABCC11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC11-001
ENSP00000349017
ENST00000356608
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
1382 aa
154.3 kDa
No >9
ABCC11-002
ENSP00000311326
ENST00000353782
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6R9 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
1344 aa
150.1 kDa
No >9
ABCC11-004
ENSP00000378230
ENST00000394747
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
1382 aa
154.3 kDa
No >9
ABCC11-006
ENSP00000456268
ENST00000569991
H3BRJ2 [Direct mapping]
ATP-binding cassette sub-family C member 11
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
159 aa
18.1 kDa
No 0
ABCC11-201
ENSP00000378231
ENST00000394748
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
1382 aa
154.3 kDa
No >9

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  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
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