Weak to moderate cytoplasmic positivity with a granular pattern was observed in most malignant cells. Several cases of cholangiocarcinomas and thyroid cancers were strongly stained. A majority of squamous cell carcinomas were weakly stained or negative.
Most of the cancer tissues displayed moderate to strong cytoplasmic, often with a perinuclear accentuation along with additional nuclear staining in some cases. Several cases of lymphomas and renal cancers were negative.
Cancer tissues showed moderate to strong cytoplasmic staining in a granular pattern. Several cases of squamous cell carcinomas, lymphomas, stomach, liver and colorectal cancers were weakly stained or negative.
Moderate to strong cytoplasmic staining was observed in cancer tissues.
ABCC11 (HGNC Symbol)
ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]