Fields »
ABOUT
HELP
BLOG
ABCC11

GENERAL INFORMATION

Gene name

 ABCC11

Gene description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 11

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, prostate cancer)
HPA (cell line):Cell line enriched (T-47d)
HPA (normal tissue):Tissue enriched (breast)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 4 antibodies.
HPA031980 , HPA031981 , HPA031982 , CAB032513
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031980
HPA031981
HPA031982
CAB032513

GENE INFORMATION

Gene name

 ABCC11 (HGNC Symbol)

Synonyms

 MRP8

Description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 48166910 - 48247568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121270 (version 83.38)

Entrez gene

 85320

UniProt

 Q96J66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96J66

Antibodypedia

 ABCC11 antibodies

PROTEIN BROWSER
ABCC11-001
ABCC11-002
ABCC11-004
ABCC11-006
ABCC11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCC11-001
ENSP00000349017
ENST00000356608
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 1382 aa
154.3 kDa 		No >9
ABCC11-002
ENSP00000311326
ENST00000353782
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6R9 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 1344 aa
150.1 kDa 		No >9
ABCC11-004
ENSP00000378230
ENST00000394747
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 1382 aa
154.3 kDa 		No >9
ABCC11-006
ENSP00000456268
ENST00000569991
H3BRJ2 [Direct mapping]
ATP-binding cassette sub-family C member 11
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 159 aa
18.1 kDa 		No 0
ABCC11-201
ENSP00000378231
ENST00000394748
Q96J66 [Direct mapping]
ATP-binding cassette sub-family C member 11
A0A024R6Q6 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015216 [purine nucleotide transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015865 [purine nucleotide transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 1382 aa
154.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.