Tissue expression of ABCC11 - Summary - The Human Protein Atlas

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ABCC11

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABCC11
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (breast)
GTEx:	Group enriched (breast, liver, prostate, testis)
FANTOM5:	Tissue enhanced (epididymis, retina)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 4 antibodies. HPA031980 , HPA031981 , HPA031982 , CAB032513
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (breast)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (breast, liver, prostate, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (epididymis, retina)

GENE INFORMATION
Gene name	ABCC11 (HGNC Symbol)
Synonyms	MRP8
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	48166910 - 48247568
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121270 (version 83.38)
Entrez gene	85320
UniProt	Q96J66 (UniProt - Evidence at protein level)
neXtProt	NX_Q96J66
Antibodypedia	ABCC11 antibodies

PROTEIN BROWSER

ABCC11-001	ABCC11-002	ABCC11-004	ABCC11-006	ABCC11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC11-001 ENSP00000349017 ENST00000356608	Q96J66 [Direct mapping] ATP-binding cassette sub-family C member 11 A0A024R6Q6 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015216 [purine nucleotide transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015865 [purine nucleotide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1382 aa 154.3 kDa	No	>9
ABCC11-002 ENSP00000311326 ENST00000353782	Q96J66 [Direct mapping] ATP-binding cassette sub-family C member 11 A0A024R6R9 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015216 [purine nucleotide transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015865 [purine nucleotide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1344 aa 150.1 kDa	No	>9
ABCC11-004 ENSP00000378230 ENST00000394747	Q96J66 [Direct mapping] ATP-binding cassette sub-family C member 11 A0A024R6Q6 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015216 [purine nucleotide transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015865 [purine nucleotide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1382 aa 154.3 kDa	No	>9
ABCC11-006 ENSP00000456268 ENST00000569991	H3BRJ2 [Direct mapping] ATP-binding cassette sub-family C member 11 Show all	Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	159 aa 18.1 kDa	No	0
ABCC11-201 ENSP00000378231 ENST00000394748	Q96J66 [Direct mapping] ATP-binding cassette sub-family C member 11 A0A024R6Q6 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family C (CFTR/MRP), member 11, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015216 [purine nucleotide transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015865 [purine nucleotide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1382 aa 154.3 kDa	No	>9

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The Human Protein Atlas

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