Cell atlas - ADCY7 - The Human Protein Atlas

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ADCY7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ADCY7
Gene description	Adenylate cyclase 7
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041218
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041218	HaCaT	Cytosol
	HPA041218	U-2 OS	Cytosol

GENE INFORMATION
Gene name	ADCY7 (HGNC Symbol)
Synonyms	AC7, KIAA0037
Description	Adenylate cyclase 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	50246137 - 50318135
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121281 (version 83.38)
Entrez gene	113
UniProt	P51828 (UniProt - Evidence at transcript level)
neXtProt	NX_P51828
Antibodypedia	ADCY7 antibodies

PROTEIN BROWSER

ADCY7-001	ADCY7-002	ADCY7-006	ADCY7-009	ADCY7-014	ADCY7-201	ADCY7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCY7-001 ENSP00000378187 ENST00000394697	P51828 [Direct mapping] Adenylate cyclase type 7 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0004016 [adenylate cyclase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019933 [cAMP-mediated signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0060135 [maternal process involved in female pregnancy] GO:0071361 [cellular response to ethanol] GO:0071377 [cellular response to glucagon stimulus] Show all	1080 aa 120.3 kDa	No	>9
ADCY7-002 ENSP00000457409 ENST00000566433	F5H4D1 [Direct mapping] Adenylate cyclase type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004016 [adenylate cyclase activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0035556 [intracellular signal transduction] Show all	734 aa 81.5 kDa	No	8
ADCY7-006 ENSP00000460018 ENST00000569265	I3L2Y1 [Direct mapping] Adenylate cyclase type 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.9 kDa	No	0
ADCY7-009 ENSP00000454301 ENST00000566761	H3BMA5 [Direct mapping] Adenylate cyclase type 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 11.9 kDa	No	0
ADCY7-014 ENSP00000460636 ENST00000564965	I3L3Q5 [Direct mapping] Adenylate cyclase type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	81 aa 8.7 kDa	No	1
ADCY7-201 ENSP00000254235 ENST00000254235	P51828 [Direct mapping] Adenylate cyclase type 7 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0004016 [adenylate cyclase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019933 [cAMP-mediated signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0071361 [cellular response to ethanol] GO:0071377 [cellular response to glucagon stimulus] Show all	1080 aa 120.3 kDa	No	>9
ADCY7-202 ENSP00000437788 ENST00000537579	F5H699 [Direct mapping] Adenylate cyclase type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0035556 [intracellular signal transduction] Show all	433 aa 48.1 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.