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Malignant tissues displayed moderate to strong cytoplasmic positivity. Additional membranous staining was observed in malignant melanomas, colorectal and urothelial cancers.
Most of the malignant cells showed moderate cytoplasmic and/or nuclear immunoreactivity. A few colorectal cancers were strongly stained.
GENE INFORMATION
Gene name
KIF18A (HGNC Symbol)
Synonyms
DKFZP434G2226, PPP1R99
Description
Kinesin family member 18A (HGNC Symbol)
Entrez gene summary
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]