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KHDRBS1

GENERAL INFORMATION

Gene name

 KHDRBS1

Gene description

 KH domain containing, RNA binding, signal transduction associated 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA051280 , HPA056813 , CAB005355
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KHDRBS1 (HGNC Symbol)

Synonyms

 FLJ34027, p62, Sam68

Description

 KH domain containing, RNA binding, signal transduction associated 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 32013829 - 32060850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121774 (version 83.38)

Entrez gene

 10657

UniProt

 Q07666 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07666

Antibodypedia

 KHDRBS1 antibodies

PROTEIN BROWSER
KHDRBS1-001
KHDRBS1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KHDRBS1-001
ENSP00000313829
ENST00000327300
Q07666 [Direct mapping]
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008143 [poly(A) binding]
GO:0008266 [poly(U) RNA binding]
GO:0008283 [cell proliferation]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045948 [positive regulation of translational initiation]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046833 [positive regulation of RNA export from nucleus]
GO:0070618 [Grb2-Sos complex]
Show all
 443 aa
48.2 kDa 		No 0
KHDRBS1-003
ENSP00000417731
ENST00000492989
Q07666 [Direct mapping]
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008143 [poly(A) binding]
GO:0008266 [poly(U) RNA binding]
GO:0008283 [cell proliferation]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045948 [positive regulation of translational initiation]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046833 [positive regulation of RNA export from nucleus]
Show all
 404 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.