Expression of CCRL2 in cancer - Summary - The Human Protein Atlas

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CCRL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCRL2
Gene description	Chemokine (C-C motif) receptor-like 2
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, PC-3, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043238
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and urothelial cancer (favourable).
Colorectal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043238

GENE INFORMATION
Gene name	CCRL2 (HGNC Symbol)
Synonyms	ACKR5, CKRX, CRAM-A, CRAM-B, HCR
Description	Chemokine (C-C motif) receptor-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46407163 - 46412997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121797 (version 83.38)
Entrez gene	9034
UniProt	O00421 (UniProt - Evidence at protein level)
neXtProt	NX_O00421
Antibodypedia	CCRL2 antibodies

PROTEIN BROWSER

CCRL2-001	CCRL2-002	CCRL2-003	CCRL2-004	CCRL2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCRL2-001 ENSP00000349967 ENST00000357392	O00421 [Direct mapping] C-C chemokine receptor-like 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	356 aa 41 kDa	No	7
CCRL2-002 ENSP00000381994 ENST00000399036	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-003 ENSP00000383678 ENST00000400882	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-004 ENSP00000383677 ENST00000400880	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-005 ENSP00000414957 ENST00000433848	C9JP23 [Direct mapping] C-C chemokine receptor-like 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	217 aa 24.6 kDa	No	5

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The Human Protein Atlas

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